The two will face each other on Monday night in the Nations League and Ramos, who is no stranger to controversy following his exploits in the Champions League final against Liverpool, singled out Kane for praise before the match in Seville.
The Football Association has shown its faith in Southgate with a new four-year contract and there is hardly a mood of "be all or end all" around these games, but the question of qualification still leaves the manager trying to perform a delicate balancing act.
A good performance and result here in Seville will avoid further dilution of the summer feel-good factor and a revisiting of the view muttered by some that England were beneficiaries of a kind draw in Russian Federation and failed against the top-class sides when it mattered. We are playing this unique football again. The signs are good. We dictated the flow for a long period.
It was perhaps inevitable that a game played in such an artificial atmosphere took 45 minutes to get going - and to suggest it then became a thriller would be stretching credibility to breaking point.
Tottenham's Harry Kane is constantly a man in the spotlight and some have criticised him for his form at the beginning of the season.
"We needed to get tight to Croatia's midfield, Spain are similar in that sense".
"We were a real threat".
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"This is another chance against world-class players".
"They're a little bit more direct, more players with speed in the front three". Maybe he surprises a lot of people, but not me. I am pleased with the chances we created, and we just have to make sure we finish them, which on another day we will.
Luis Enrique did not single out an individual England player but had kind words for Southgate, who he joked was helping him improve his English.
"I like Gareth Southgate as a manager", the former Barcelona coach said. "I like the way he interprets the game by trying to play with the ball and adapting to his players, which is something we all must do".
England have just one point from their opening two games in Group 4 and lost to Spain 2-1 at Wembley earlier this month when Saul Niguez and Rodrigo scored to cancel out Marcus Rashford's opener.
Football supporters are a determined bunch and, if they want to see a game involving their team, it is often a case of "where there is a will, there is a way". "It's an opportunity to look at some younger players". Rashford was one of few England players to emerge with credit in the last worldwide break as he scored against Spain and a friendly win over Switzerland.