Sane was a key player for City as they won the Premier League title with a record points tally last season.
He was surprisingly cut from Germany's World Cup squad and found himself restricted to substitute cameos in City's opening three Premier League games - with his brief outing in the 1-1 draw at Wolves last weekend particularly error-strewn. "It's nearly impossible after the World Cup, after what happened last season, mentally for the players and everybody to be in the best condition".
And as he looked ahead to the resumption of action following the current global break, Guardiola said he was in no doubt his contribution will be equally crucially this time round.
"Against Tottenham, we were really positive and really strong and I think the opponent, a very good opponent, felt that and felt they were really in trouble".
"I am so surprised that after what happened last season, the World Cup, we come back and you never know".
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Guardiola has pledged to omit the Brazilian at times, though he accepts he is hard to replace, explaining: "Fernandinho is a gift". He will continue training, and hopefully we will see the best of him in a few months.
Closing out September is a home game against Brighton, and their win over Manchester United proves they are no pushover, but City dispatched of Chris Hughton's team twice last season and should win again.
Raheem Sterling, John Stones and Kyle Walker celebrate a goal.
"We will not play against Man City every weekend".
"It's about good ball connection and getting it on target. He has an unbelievable strike, and that proved it".