Williams counts six US Open victories among her 23 Slams and with one more would match Australian Margaret Court's record for most major singles titles.
Serena Williams may have only won $62,000 in prize money during the last 12 months, but she has still topped Forbes' list of the world's highest-earning female athletes.
Second seed and two-time runner-up Caroline Wozniacki opens against 2011 victor Samantha Stosur, while reigning champion Sloane Stephens, who is seeded third, will begin her defense against Evgeniya Rodina.
American former professional racing driver Danica Patrick is the only other non-tennis player in the top 10, at No. 9, sandwiched between Halep and Kerber.
Saudi Arabia barring Hajj pilgrims, Qatar says
The four countries accused Qatar of sponsoring " terrorism " and destabilizing the region, an allegation strongly denied by Doha. After sunset, pilgrims will head to Muzdalifah, half-way between Arafat and Mina, where they will stay at least until midnight.
Kerala floods: 1 mn people in relief camps, says Tourism Minister
He said the department was preparing to deal with a possible outbreak of water-borne and air-borne diseases in the camps. Train services between Thiruvananthapuram and Ernakulam are gradually becoming normalised, news agency PTI reported.
On MSNBC, Omarosa Says Trump ‘Wants to Start a Race War’
It also referred to Manigault-Newman's job title as White House director of communications. We still wanted her on our team because we cared so much about her personally.
Williams, 36, has had a roller coaster return to tennis since the birth of her daughter.
Federer lost in the quarterfinals last year and this time in that round could face No. 6 seed Djokovic, the Wimbledon champion who beat him two weeks ago in a tuneup and is considered a tournament favorite after having to miss it last year because of injury.
If the sisters do play each other, the victor might face world number one Simona Halep in the fourth round.
In June, United States Tennis Association president Katrina Adams said the US Open would revise seedings to take into account the effect of pregnancy on the current rankings of players.
Should the unseeded Murray advance, he would face Fernando Verdasco or Feliciano Lopez of Spain in the second round before a projected third-round clash against Argentine third seed and 2009 champion Juan Martin del Potro.
In the men's field, No. 1-ranked and defending champion Rafael Nadal opens against David Ferrer in an all-Spanish rematch of their 2013 French Open final.