Yad Vashem's Chairman Avner Shalev will accompany Prince William who will participate in a memorial ceremony in the Hall of Remembrance, visit the Children's Memorial, and sign the Yad Vashem Guest Book.
Though the trip is being billed as non-political, and places a special emphasis on technology and joint Israeli-Arab projects, William will also be meeting with Israeli and Palestinian leaders, and visiting landmark Jerusalem sites at the heart of the century-old conflict.
William arrived in Jordan at the start of a Middle East tour.
In signing the Yad Vashem guestbook, the prince called it a "profoundly moving experience" and said the Holocaust was "almost impossible to comprehend". His great-grandmother, Princess Alice of Greece - the mother of the Duke of Edinburgh - is recognised by the memorial for her role in rescuing Jews during the Holocaust by hiding three members of a family called Cohen in her palace in Athens during the Nazi occupation of Greece.
Prince William made sure to take a photo of himself in the same location as his wife some thirty years ago, and it will surely be shown to the couple's three children, Prince George, Princess Charlotte and Prince Louis when he returns to Kensington Palace in a few days.
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Thanks to her, the Cohen family survived and today lives in France, it said.
Later in the day, William planned to meet young people participating in a soccer-based youth programme in Tel Aviv and deliver a speech at a reception at the British ambassador's residence.
During the four-day visit, William is also scheduled to meet Palestinian President Mahmoud Abbas and Palestinian youngsters in the occupied West Bank. "And he really wants to get under the skin of the country", Quarrey added. Even so, many Israelis were displeased that the British government chose to use the wording of the prince's itinerary to drive home the point that it doesn't accept Jewish sovereignty over Jerusalem.
The prince's visit comes at a time of heightened tensions in the region, with deadly clashes on the Gaza border following protests as Israel marks its 70th anniversary year, and U.S. president Donald Trump's decision to move the U.S. embassy from Tel Aviv to Jerusalem. The Palestinians claim east Jerusalem as their future capital.