The Russian military said on Monday that two Israeli war planes carried out strikes on Syrian regime air base from Lebanese air space with eight missiles after USA and France denied responsibilty for the attack.
Earlier, Syrian state media had spoken of dead and wounded at the base, without giving casualty figures.
The IDF shot down the drone, and dispatched a battery of planes to attack the Tadmor air base in Syria, where the drone was dispatched from, and several other targets in Syria.
The Pentagon was suspected to be conducting air strikes in Syria after receiving threats about chemical attacks.
On Sunday, President Donald Trump warned the Syrian government it would pay a "big price" for the suspected chemical weapons attack.
Since 2012, Israel has struck inside Syria more than 100 times, mostly targeting suspected weapons convoys destined for the Lebanese militant group Hezbollah, which has been fighting alongside Syrian government forces.
"At this time, the Department of Defense is not conducting air strikes in Syria", the Pentagon said in a statement.
Syria's White Helmets, who act as first responders in rebel-held areas of Syria, said the Douma attack took place late on Saturday using "poisonous chlorine gas".
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The agency said it was likely "an American aggression" but US officials say the United States had not launched airstrikes on Syria.
"There was no chemical-weapons attack", Nebenzya said, adding that Syria and Russian Federation had invited the worldwide chemical-weapons watchdog to inspect the site.
Turkey attacked Afrin in March to drive out the Kurdish militia, known as the YPG, which forms the backbone of the Syrian Democratic Forces, America's main partner in Syria.
Trump referred in a Tweet to "Animal Assad" and criticised Russia and Iran for backing the Syrian leader, directly naming Russian President Vladimir Putin.
Israel military, which already bombed the T-4 airbase in February, refused to give any comments to Sputnik about the airstrike on the facility. The gas attack was blamed on Assad.
French President Emmanuel Macron spoke to Trump by telephone and the two agreed that they would work together to establish clear responsibility for what Macron's office said they had agreed was a confirmed chemical attack. Russia, Assad's ally, said such accounts were "fabricated". It also, perhaps, came as a bit of a surprise as Trump has often been criticised for his lack of the same towards his Russian counterpart for his country's alleged involvement in the meddling of the 2016 United States presidential election.
USA government sources said Washington's assessment of the Saturday attack was that chemical weapons were used.
It is believed the strikes are in response to an alleged chemical gas attack on Saturday.
The United Nations also weighed in, saying that the alleged use of chemical weapons if true is "abhorrent". The European Union also said evidence pointed to the use of chemical weapons by Assad's forces.