Janney was presented the trophy by last year's Best Supporting Actor victor Mahershala Ali.
"Okay, nothing further - nothing further from the truth", Janney continued as she thanked the Academy and praised the "extraordinary" nominees.
Janney also recognized her "I, Tonya" family ("a cast and crew and bird that elevated my work"), as well as Neon and 30 West.
She portrays an abusive mother who pushes her daughter, Tonya Harding, to become a world-class figure skater even while she destroys Tonya's self-esteem.
Here's what the Twitterverse had to say about Janney's first Oscar nomination and win.
Janney plays Harding's vile mother, LaVona Fay Golden.
Being bed-bound is the last thing Janney needs in her already drama-packed life right now. "I love you very much". [But] without them, I don't know where I would be right now. "So I'm happy that I have "Mom" -- the people at "Mom" to lift me up and keep me -- keep me going and keep me focused", she said.
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The actress said she was grateful to "I, Tonya" screenwriter Steven Rogers. "You're always in my heart".
Hal's battles influenced Janney to take on the role of Bonnie Plunkett, a recovering addict, in "Mom".
When Janney arrived backstage to an interview room to talk with reporters, she promptly removed her shoes.
She threw them off again.
Asked if her day-to-day life might change now that she's an Oscar victor, Janney said she had to go right back to work at 10 a.m. Monday for a table read for her CBS sitcom "Mom".
"My parents came to see me in everything I did growing up", she remembers. "There are going to be more women making decisions about what movies are made".
"I was around the world of recovery a lot, trying to get my brother to want to recover", Janney told CBS News in 2016. "I bow down to her". "At a certain point I had given up thinking this could happen to me".